Tetrahedron Letters p. 4085 - 4088 (1999)
Update date:2022-08-03
Topics:
Jones, Raymond C. F.
Dawson, Claire E.
O'Mahony, Mary J.
Patel, Pravin
The 1,3-dipolar cycloaddition of the β-aminonitrile oxide, formed from β-alanine, to the enamine of a β-ketoester affords a 3-(2- aminoalkyl)isoxazole-4-carboxylic ester that is converted via isoxazolo[4,5- c]pyridin-4-ones into 3-acetyl-4-hydroxypyridin-2-ones.
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