Base assisted substitution of α-amidoalkyl sulfones by nitromethane anion. A new entry to functionalized α-amino acids

Article abstract of DOI:10.1016/S0040-4039(99)00770-4

The nitromethane anion reacts with α-amidoalkyl sulfones in THF affording the corresponding nitro derivatives that upon oxidation with alkaline potassium permanganate give the corresponding N-protected α-amino acids.