One-pot synthesis of 2,3-disubstituted naphtho[2,3-b]thiophene-4,9-diones from a 2-sulfenyl-1,4-naphthoquinone and enamines

Article abstract of DOI:10.1246/cl.1999.503

The title naphthothiophenequinone derivatives were generally synthesized in one-pot using a tandem conjugate addition-cyclization sequence between 2-[2-(ethoxycarbonyl)-ethyl]thio-1,4-naphthoquinone and enamines, derived from cyclic and acyclic ketones.