ARYLTETRALIN LIGNANS FROM PODOPHYLLUM HEXANDRUM AND PODOPHYLLUM PELTATUM

Article abstract of DOI:10.1016/S0031-9422(00)82628-X

Roots of Podophyllum hexandrum and P. peltatum contain the same range of ten aryltetralin lignans: podophyllotoxin, 4'-demethylpodophyllotoxin, α-peltatin, β-peltatin, desoxypodophyllotoxin, podophyllotoxone, isopicropodophyllone, 4'-demetyldesoxypodophyllotoxin, 4'-demethylpodophyllotoxone and 4'-demethylisopicropodophyllone, although the relative proportions are markedly different.The latter two compounds are previously unreported natural products, but 4'-demethylisopicropodophyllone may well be an artefact resulting from epimerization of 4'-demethylpodophyllotoxone.The peltatins have not previously been isolated from P. hexandrum.Key Word Index - Podophyllum hexandrum; P. peltatum; Podophyllaceae; aryltetralin; lignans; podophyllotoxin.