Journal of medicinal chemistry p. 3388 - 3390 (1991)
Update date:2022-08-03
Topics:
Thompson
Secunda
Daly
Olsson
Radioligand binding studies of N6-substituted adenosines at the A1 and A2 adenosine receptors of rat brain cortex and rat brain striatum, respectively, show that a 2-chloro substituent does not consistently change the affinity or the selectivity of these analogues for the A1 receptor. A 2-chloro substituent lowers the characteristic stereoselectivity of the A1 receptor toward the R diastereomer of N6-(1-phenyl-2-propyl)adenosine. A 2-chloro substituent consistently increases potency of N6-substituted adenosines as agonists at an adenosine A2 receptor stimulatory to adenylate cyclase in PC12 cell membranes.
View MoreTaizhou Chenyi chemical co. LTD,
Contact:13736652831
Address:NO.273 SHANGHAI SOUTH STREET,LUQIAO DISTRICT,ZHEJIANG PROVINCE,CHINA.
Contact:0571-
Address:zhejing
Contact:13120882795;+86-21-34621078;+86-021-31122318
Address:Suite 2,No.2715 Longwu Road
Hebei Fulong Import & Export Co., Ltd.
Contact:86-311-87795661
Address:15A19 Zhongyuan Building,368 Youyi North Street,Shijiazhuang 050070,China
Wuxi Zuping Food Science And Technology Co.,LTD.
Contact:+86-510-87210822
Address:Guanlin town
Doi:10.1080/07328300802272389
(2008)Doi:10.1039/b923855g
(2010)Doi:10.1021/ol5024689
(2014)Doi:10.1021/ja01219a011
(1945)Doi:10.1021/jm00263a029
(1973)Doi:10.3762/bjoc.14.218
(2018)