Total syntheses of all four stereoisomers of piscidic acid via catalytic asymmetric dihydroxylation of (Z)- and (E)-trisubstituted olefins

Article abstract of DOI:10.1271/bbb.63.1934

All four stereoisomers of (2S, 3R)-(+)-piscidic acid were synthesized with high optical purity via Sharpless catalytic asymmetric dihydroxylation of (Z)- and (E)-trisubstituted olefins in 6 steps from (4-hydroxyphenyl)pyruvic acid. The Wittig reaction of