2,4,6-Triarylchalcogenopyrylium Dyes
J ournal of Medicinal Chemistry, 1999, Vol. 42, No. 19 3951
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Ad m in istr a tion of Dyes 2-4. Stock solutions of dyes 2-4
at 5 mg of dye/mL in 1% ethanol/0.9% NaCl were prepared by
first dissolving the dye in ethanol and diluting to the appropri-
ate volume with 0.9% NaCl. When R3230AC tumors reached
0.50-0.60 cm in diameter (0.1-0.17 cm3), usually 7-12 days
after tumor implantation, the animals were given 200 µL of
the dye solution (10 mg of dye/kg; 20 µmol/kg for dye 2, 19
µmol/kg for dye 3, 17 µmol/kg for dye 4) via tail-vein injection.
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Ack n ow led gm en t. The authors thank the National
Institutes of Health (Grant CA69155 to M.R.D. and
Grant CA36856 to R.H.) for support of this work.
Su p p or tin g In for m a tion Ava ila ble: Figures 4 and 5 for
dark and phototoxicity of dyes 3 and 4, respectively. This
material is available free of charge via the Internet at http://
pubs.acs.org.
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