Reaction of 1,2-dibromoethane with primary amines: Formation of N,N′-disubstituted ethylenediamines RNH-CH2CH2-NHR and homologous polyamines RNH-[CH2CH2NR]n-H

DOI: 10.1016/S0040-4020(03)01149-9

Source and publish data:

Tetrahedron p. 7565 - 7570 (2003)

Update date:2022-09-26

Topics:

Authors:

Denk, Michael K.

Krause, Mike J.

Niyogi, Debyani F.

Gill, Nachhattarpal K.

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Article abstract of DOI:10.1016/S0040-4020(03)01149-9

The reaction of primary amines RNH₂ (R: Me, Et, iPr, tBu and Ph) with 1,2-dibromoethane gave N,N′-disubstituted ethylenediamines R-NH-CH₂CH₂-NH-R (1) in yields ranging from 10% (1a; R=Me) to 70% (1d, R=tBu; 1e, R=Ph). Pipe

Full text of DOI:10.1016/S0040-4020(03)01149-9

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