Reaction of chiral titanium Z-enolates with chiral α-silyloxy aldehydes. Syntheses of NFX-2 and antimycinone

DOI: 10.1016/S0040-4039(99)00987-9

Source and publish data:

Tetrahedron Letters p. 5083 - 5086 (1999)

Update date:2022-07-30

Topics:

Authors:

Esteve, Cristina

Ferrero, Monica

Romea, Pedro

Urpi, Felix

Vilarrasa, Jaume

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(99)00987-9

Titanium-mediated aldol reactions of 1 and (S)-2-tert- butyldiphenylsilyloxy aldehydes (matched pair) afford syn Felkin diastereomers in excellent yield and absolute stereochemical control. Having established that chain length does not affect the yield of the titanium aldol reactions, we have been able to achieve short, high yielding and enantioselective syntheses of NFX-2 and Antimycinone.

Full text of DOI:10.1016/S0040-4039(99)00987-9

Products guided by the article

Product name:(2S,4R,5R,6S)-2-tert-butyldimethylsilyloxy-6-tert-butyldiphenylsilyloxy-4-hexyl-5-hydroxy-3-heptanone

Cas No:245073-33-0

R&D Labs maybe for 245073-33-0

Shanghai ZaiQi Bio-Tech Co., Ltd.,

Contact:+86-21-5482 4098

Address:Bldg. No.7, No.201 MinYi Rd，Songjiang CaoHeJing High-Tech Park Shanghai 201516 P,R,China
Changzhou Xuanming Chemical Co., Ltd.

Contact:86 0519 85525329

Address:China Town, Xinbei, Changzhou, Jiangsu Room 6019
Tianjin Jiuri New Materials Co., Ltd.

Contact:+86-22-58889220

Address:C-5/6, Vison Hill, No.1 Gonghua Road, Huayuan Hi-tech Park, Tianjin, China.
AURORA CHEMICAL CO., LTD

Contact:86-532-68629711 13780605697

Address:NO 220 YANAN 3 ROAD,(POST ADMINISTRATION BUILDING),QINGDAO,CHINA
CHENGDU CHENLV HERB CO.,LTD

Contact:+86-28-88523492

Address:714rooms of Time Square, Pujiang County

Relevant to this article

Copper-catalyzed oxidative cross-coupling of α-aminocarbonyl compounds with primary amines toward 2-oxo-acetamidines

Doi:10.1039/c7ob02012k
(2017)
Design, synthesis, and biological evaluation of 5-aminotetrahydroquinoline-based LSD1 inhibitors acting on Asp375

Doi:10.1002/ardp.202100102
(2021)
7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5- tetrahydro-1H-1-benzazepine (OPC-41061): A potent, orally active nonpeptide arginine vasopressin V₂ receptor antagonist

Doi:10.1016/S0968-0896(99)00101-7
(1999)
A novel approach for the synthesis of 5-substituted tetrazole derivatives from primary amides in mild one-step method

Doi:10.1016/S0040-4039(97)00052-X
(1997)
Highly efficient and selective displacement of alkylthio group on acylketene O,S-acetals by organocopper reagents: A novel route to 2-alkoxy/aryloxy-1-alkenylketones

Doi:10.1016/0040-4039(95)01990-Y
(1995)
Porphyrin clips derived from diphenylglycoluril. Synthesis, conformational analysis, and binding properties

Doi:10.1021/jo990112c
(1999)

Article Doi