Reaction of chiral titanium Z-enolates with chiral α-silyloxy aldehydes. Syntheses of NFX-2 and antimycinone

DOI: 10.1016/S0040-4039(99)00987-9

Source and publish data:

Tetrahedron Letters p. 5083 - 5086 (1999)

Update date:2022-07-30

Topics:

Authors:

Esteve, Cristina

Ferrero, Monica

Romea, Pedro

Urpi, Felix

Vilarrasa, Jaume

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Article abstract of DOI:10.1016/S0040-4039(99)00987-9

Titanium-mediated aldol reactions of 1 and (S)-2-tert- butyldiphenylsilyloxy aldehydes (matched pair) afford syn Felkin diastereomers in excellent yield and absolute stereochemical control. Having established that chain length does not affect the yield of the titanium aldol reactions, we have been able to achieve short, high yielding and enantioselective syntheses of NFX-2 and Antimycinone.

Full text of DOI:10.1016/S0040-4039(99)00987-9

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