Synthesis and evaluation of hydroxyproline-derived isoprenyltransferase inhibitors

DOI: 10.1016/S0960-894X(99)00342-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2095 - 2100 (1999)

Update date:2022-09-26

Topics:

Authors:

O'Connell, Celeste E.

Ackermann, Karen

Rowell, Cheryl A.

Garcia, Ana Maria

Lewis, Michael D.

Schwartz, C. Eric

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00342-X

A series of peptidomimetics based on a hydroxyproline scaffold was prepared and evaluated for inhibition of farnesyltransferase and geranylgeranyltransferase I in both enzymatic and cell-based assays. A number of analogs were potent and selective inhibito

Full text of DOI:10.1016/S0960-894X(99)00342-X

Products guided by the article

Product name:(S)-4-Methylsulfanyl-2-[((2S,4S)-4-phenoxy-pyrrolidine-2-carbonyl)-amino]-butyric acid methyl ester

Cas No:245420-37-5

R&D Labs maybe for 245420-37-5

MINS GROUP CO.,LIMITED

Contact:18669908765

Address:Zibo City, Shandong Province, P.R.China
JIANGXI ZHANGFENG CHEMICAL CO., LTD.

Contact:+86-0799-3413066

Address:Xiyuan village, Xiabu Town, Xiangdong District
Guangzhou PI & PI Biotech Inc. Ltd.

Contact:+86-20-81716320

Address:13th Floor, Xinbao Technology Industrial Park, No. 2 Ruixiang Road, Huangpu District, Guangzhou,Guangdong,China
HangZhou HuaYe Chemical Technology Co.,Ltd

Contact:+86-13505815007

Address:hangzhou
ABA Chemicals (Shanghai) Limited

Contact:021- 5115 9199-232

Address:Suite 18D, #201 Ningxia Road,

Relevant to this article

Substituent effects on the kinetics of reductively-initiated fragmentation of nitrobenzyl carbamates designed as triggers for bioreductive prodrugs

Doi:10.1039/a904067f
(1999)
Facial Selectivity in the Diels-Alder Reactions of 5-Chloro-, 5-Bromo-, and 5-Iodo-l,3-cyclopentadiene and Derivatives

Doi:10.1021/jo961710j
(1997)
Ethanol as a Hydrogenating Agent: Palladium-Catalyzed Stereoselective Hydrogenation of Ynamides To Give Enamides

Doi:10.1002/anie.201702277
(2017)
Switchable Synthesis of Pyrroles and Pyrazines via Rh(II)-Catalyzed Reaction of 1,2,3-Triazoles with Isoxazoles: Experimental and DFT Evidence for the 1,4-Diazahexatriene Intermediate

Doi:10.1021/acs.joc.6b02389
(2017)
A concise atroposelective formal synthesis of (-)-steganone

Doi:10.1002/ejoc.201402761
(2014)
Regiocontrolled Synthetic Approach to α,α′-Disubstituted Unsymmetrical Ketones

Doi:10.1021/jo991559o
(2000)

Article Doi