Synthesis and evaluation of hydroxyproline-derived isoprenyltransferase inhibitors

DOI: 10.1016/S0960-894X(99)00342-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2095 - 2100 (1999)

Update date:2022-09-26

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Authors:

O'Connell, Celeste E.

Ackermann, Karen

Rowell, Cheryl A.

Garcia, Ana Maria

Lewis, Michael D.

Schwartz, C. Eric

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Article abstract of DOI:10.1016/S0960-894X(99)00342-X

A series of peptidomimetics based on a hydroxyproline scaffold was prepared and evaluated for inhibition of farnesyltransferase and geranylgeranyltransferase I in both enzymatic and cell-based assays. A number of analogs were potent and selective inhibito

Full text of DOI:10.1016/S0960-894X(99)00342-X

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