Synthesis and evaluation of hydroxyproline-derived isoprenyltransferase inhibitors

DOI: 10.1016/S0960-894X(99)00342-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2095 - 2100 (1999)

Update date:2022-09-26

Topics:

Authors:

O'Connell, Celeste E.

Ackermann, Karen

Rowell, Cheryl A.

Garcia, Ana Maria

Lewis, Michael D.

Schwartz, C. Eric

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00342-X

A series of peptidomimetics based on a hydroxyproline scaffold was prepared and evaluated for inhibition of farnesyltransferase and geranylgeranyltransferase I in both enzymatic and cell-based assays. A number of analogs were potent and selective inhibito

Full text of DOI:10.1016/S0960-894X(99)00342-X

Products guided by the article

Product name:(S)-4-Methylsulfanyl-2-[((2S,4S)-4-phenoxy-pyrrolidine-2-carbonyl)-amino]-butyric acid methyl ester

Cas No:245420-37-5

R&D Labs maybe for 245420-37-5

Engineering Research Center of Pesticide, Heilongjiang Province

Contact:+86-451-86609001

Address:No.74 of Xuefu Road, Nangang District,
Hangzhou Mole's Science & Technology Co.,Ltd.(expird)

Contact:+86-571-56880228

Address:15F Guodu development Building, NO.182 Zhaohui Road
NINGBO YINZHOU PRECISE COLOR CO.,LTD.

Contact:86-574-88139809 86-574-83033159

Address:Qiming Road,Yinzhou,Ningbo,China
Dalian Join King Biochemical Tech. Co., Ltd.

Contact:0411 39216206

Address:814 First State Blvd
Shanghai AoBo Bio-Pharmaceutical Technology Co., Ltd.

Contact:+86-21-51320130-801, 816

Address:Room 601, No. 1011, Halei Road, Zhangjiang High-Tech Park, Pudong, Shanghai

Relevant to this article

Substituent effects on the kinetics of reductively-initiated fragmentation of nitrobenzyl carbamates designed as triggers for bioreductive prodrugs

Doi:10.1039/a904067f
(1999)
Facial Selectivity in the Diels-Alder Reactions of 5-Chloro-, 5-Bromo-, and 5-Iodo-l,3-cyclopentadiene and Derivatives

Doi:10.1021/jo961710j
(1997)
Ethanol as a Hydrogenating Agent: Palladium-Catalyzed Stereoselective Hydrogenation of Ynamides To Give Enamides

Doi:10.1002/anie.201702277
(2017)
Switchable Synthesis of Pyrroles and Pyrazines via Rh(II)-Catalyzed Reaction of 1,2,3-Triazoles with Isoxazoles: Experimental and DFT Evidence for the 1,4-Diazahexatriene Intermediate

Doi:10.1021/acs.joc.6b02389
(2017)
A concise atroposelective formal synthesis of (-)-steganone

Doi:10.1002/ejoc.201402761
(2014)
Regiocontrolled Synthetic Approach to α,α′-Disubstituted Unsymmetrical Ketones

Doi:10.1021/jo991559o
(2000)

Article Doi