Synthesis and evaluation of hydroxyproline-derived isoprenyltransferase inhibitors

Article abstract of DOI:10.1016/S0960-894X(99)00342-X

A series of peptidomimetics based on a hydroxyproline scaffold was prepared and evaluated for inhibition of farnesyltransferase and geranylgeranyltransferase I in both enzymatic and cell-based assays. A number of analogs were potent and selective inhibito