Tetrahedron p. 8905 - 8914 (1999)
Update date:2022-09-26
Topics:
Martin, Stephen F.
Bur, Scott K.
A concise synthesis of (-)-3, a known precursor of pumiliotoxin 251D, has been completed using a vinylogous Mannich reaction as a key construction. Silyloxyfuran 10 added to methoxypyrrolidine 20 in the presence of TMS-OTf to give a mixture (4.8:1) of 21 and 22 in 57% yield. Reduction and global deprotection of 21 afforded the bicyclic lactam 23. Raney Nickel mediated extrusion of the hydroxymethyl group from 23 gave (-)-3.
View MoreContact:+36(21)2523420
Address:Head office: 1102 Budapest, SZENT LASZLO TER 24/B. 1/1., HUNGARY / CHINA
Shanghai Maxchemco Chemical Industry Co., Ltd.
Contact:(86)21-51079223
Address:No.1305-8, B241, the Ecust Park, Huajing Road, Xuhui District, Shanghai
Hebei Lead Bio-Chemicals Co., Ltd.
website:http://www.ldbiochem.com
Contact:+86-311-87826503
Address:481, Heping West Road, Shijiazhuang,China
Luzhou North Chemical Co., Ltd.
Contact:+86-830-2796784；+86-830-2796776
Address:Gaoba, Longmatan District, Luzhou, Sichuan Province
Shanxi Tongji Pharmaceuticals Co., Ltd.
Contact:+86-359-3024784
Address:Xikuang South Road, Ruicheng County , Shanxi
Doi:10.1016/S0968-0896(99)00064-4
(1999)Doi:10.1016/S0277-5387(99)00105-9
(1999)Doi:10.1021/om9905005
(1999)Doi:10.1039/a902224d
(1999)Doi:10.1016/j.cclet.2021.01.018
(2021)Doi:10.1016/S0022-328X(00)91414-1
(1979)
