Synthesis of a novel β-turn mimetic and its incorporation in Leu- enkephalin

Article abstract of DOI:10.1016/S0040-4039(99)01216-2

A conformationally restricted β-turn mimetic, in which an ethylene bridge replaces the intramolecular hydrogen bond between residues i and i+3 of β-turns, has been prepared and incorporated in Leu-enkephalin. Amino acids and α-bromoacids were used as building blocks in the synthesis of the mimetic.