Synthesis of 4-substituted carbocyclic 2,3-dideoxy-3-C-hydroxymethyl nucleoside analogues as potential anti-viral agents

Article abstract of DOI:10.1016/S0040-4020(99)00591-8

The synthesis of two carbocyclic guanosine analogues with an electronegative fluoro or hydroxy substituent in the 4-position is described. The cyclopentanols 17a and 18 were synthesized from enantiomerically pure 3S,4S-bis(hydroxymethyl)cyclopentanone eth