Journal of Antibiotics p. 643 - 648 (1999)
Update date:2022-09-26
Topics:
Bitha, Panayota
Li, Zhong
Lin, Yang-I
Convergent syntheses of oral THF 1β-methylcarbapenems 4 (OCA-983) and 5 starting from M2-phosphate 1 were developed. Reaction of the M2-phosphate 1 with THF thiols containing a requisite prodrug side chain, 9 and 10, gave the desired oral THF 1β-methylcarbapenems 4 and 5, respectively, in 46% and 42% overall yields.
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