Synthesis and biological evaluation of dianhydrohexitol integrin antagonists

DOI: 10.1016/S0040-4020(99)00599-2

Source and publish data:

Tetrahedron p. 10713 - 10734 (1999)

Update date:2022-08-05

Topics:

Authors:

Osterkamp, Frank

Wehlan, Hermut

Koert, Ulrich

Wiesner, Matthias

Raddatz, Peter

Goodman, Simon L.

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Article abstract of DOI:10.1016/S0040-4020(99)00599-2

The synthesis of a series of RGD mimetics is described. All compounds have a 1.4:3.6dianhydrohexitol core. a variable linker to a guanidino group, and a serine ether to mimic the carboxylic acid. Two types of linkers were combined with 1.4:3.6-dianhydro-D

Full text of DOI:10.1016/S0040-4020(99)00599-2

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Product name:(2'S)-5-O-allyl-2-O-[2'-(benzyloxycarbonylamino)-methyl propionate-3'-yl]-1,4:3,6-dianhydro-D-sorbitol

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