Bioorganic and Medicinal Chemistry Letters p. 2385 - 2390 (1999)
Update date:2022-08-05
Topics:
Kang, Yong Koo
Shin, Kye Jung
Yoo, Kyung Ho
Seo, Kyung Jae
Park, Seung Yong
Kim, Dong Jin
Park, Sang Woo
The synthesis and biological activity of the novel series of 1β- methylcarbapenems 1a-f, bearing a variety of 3'',4''-disubstituted pyrrolidinamides as substituents at C-2, are described. Of these carbapenems, diol 1a showed the most potent and well balanced antibacterial activity against Gram-positive and Gram-negative, 1a was also evaluated for pharmacokinetics and in vivo therapeutic efficacy in systemic infections.
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Doi:10.1002/(SICI)1522-2675(19990908)82:9<1360::AID-HLCA1360>3.0.CO;2-V
(1999)Doi:10.1021/om990347e
(1999)Doi:10.1016/S0957-4166(99)00285-2
(1999)Doi:10.1007/s12039-012-0355-9
(2013)Doi:10.1016/j.tetasy.2005.08.004
(2005)Doi:10.1016/S0040-4039(99)00143-4
(1999)
