Conformationally locked nucleosides. Synthesis of oligodeoxynucleotides containing 3'-amino-3'-deoxy-3'-N,5'(R)-C-ethylenethymidine

Article abstract of DOI:10.1080/15257770008033851

3'-Amino-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-N,5'(R)-C-ethylenethymidine (6) was synthesized starting from 3'-azido-3'-deoxythymidine. Condensation of 6 with 5'-O-(H-phosphonyl)thymidine and 5'-O-(p-nitrophenoxycarbonyl)thymidine derivatives gave dinucleotide and dinucleoside derivatives, respectively, which were incorporated into oligodeoxynucleotides (ODNs). Tm data of the modified ODNs are also presented.

Full text of DOI:10.1080/15257770008033851

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Nucleosides, Nucleotides and Nucleic
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Conformationally Locked Nucleosides.
Synthesis of Oligodeoxynucleotides
Containing 3′-Amino-3′-deoxy-3′-
N,5′(R)-C-ethylenethymidine
Guangyi Wang a & Vesna Stoisavljevic a
a Chemistry Laboratory, ICN Pharmaceuticals, Inc. , 3300 Hyland
Avenue Costa Mesa, California, 92626, U.S.A.
Published online: 24 Sep 2006.
To cite this article: Guangyi Wang & Vesna Stoisavljevic (2000) Conformationally Locked Nucleosides.
Synthesis of Oligodeoxynucleotides Containing 3′-Amino-3′-deoxy-3′-N,5′(R)-C-ethylenethymidine,
Nucleosides, Nucleotides and Nucleic Acids, 19:9, 1413-1425, DOI: 10.1080/15257770008033851
To link to this article: http://dx.doi.org/10.1080/15257770008033851
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