Bioorganic and Medicinal Chemistry Letters p. 2359 - 2364 (1999)
Update date:2022-08-04
Topics:
Buchanan, John L.
Vu, Chi B.
Merry, Taylor J.
Corpuz, Evelyn G.
Pradeepan, Selvaluxmi G.
Mani, Ukti N.
Yang, Michael
Plake, Hilary R.
Varkhedkar, Vaibhav M.
Lynch, Berkley A.
MacNeil, Ian A.
Loiacono, Kara A.
Tiong, Choi Lai
Holt, Dennis A.
The structure-activity relationships (SAR) of a novel class of Src SH2 inhibitors are described. Variation at the pY+1 and pY+3 side chain positions using 2,4- and 2,5-substituted thiazoles and 1,2,4-oxadiazoles as scaffolds resulted in inhibitors that bound as well as the standard tetrapeptide Ac- pYEE1-NH2.
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Doi:10.1016/j.abb.2013.10.007
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(1955)
