Amino acids and peptides. LIV. Application of 2-adamantyl derivatives as protecting groups to the synthesis of peptide fragments related to Sulfolobus solifataricus ribonuclease. I

DOI: 10.1248/cpb.47.1089

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1089 - 1096 (1999)

Update date:2022-08-05

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Authors:

Okada, Yoshio

Joshi, Shima

Shintomi, Noriyuki

Kondo, Yukihiro

Tsuda, Yuko

Ohgi, Kazuko

Irie, Masachika

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Article abstract of DOI:10.1248/cpb.47.1089

The 2-adamantyloxycarbonyl group was employed for the protection of the ε-amino group of Lys and the hydroxyl group of Tyr, and the 2-adamantyl ester was employed for the protection of the β-carboxyl group of Asp in order to construct eight peptide segments as building blocks for the preparation of peptide fragments related to the sequence of Sulfolobus solifataricus Ribonuclease. The usefulness of the above protecting groups developed in our laboratory was confirmed.

Full text of DOI:10.1248/cpb.47.1089

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