Bioorganic and Medicinal Chemistry Letters p. 2259 - 2262 (1999)
Update date:2022-08-03
Topics:
Kaltenbach III, Robert F.
Klabe, Ronald M.
Cordova, Beverly C.
Seitz, Steven P.
A series of alkyl substituted P1/P1' analogs was prepared in an attempt to increase translation of the 3-aminoindazole class of HIV protease inhibitors. Increasing the lipophilicity of the P1/P1' residues dramatically improved translation of enzyme activity to antiviral activity in the whole cell assay.
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Doi:10.1021/ol9908981
(1999)Doi:10.1039/C8CE01917G
(2019)Doi:10.1016/S0040-4020(01)82981-1
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(1999)Doi:10.1039/jr9390001069
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(1999)
