Stereoselective synthesis of 2,6-disubstituted morpholines from chiral non-racemic lactams

DOI: 10.1016/S0040-4039(99)01530-0

Source and publish data:

Tetrahedron Letters p. 7227 - 7230 (1999)

Update date:2022-08-05

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Authors:

Bouron, Estelle

Goussard, Geraldine

Marchand, Christophe

Bonin, Martine

Pannecoucke, Xavier

Quirion, Jean-Charles

Husson, Henri-Philippe

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Article abstract of DOI:10.1016/S0040-4039(99)01530-0

Optically pure 2,6-disubstituted morpholines 11 have been obtained by diastereoselective alkylation of 6-substituted 3-oxo morpholines 1 derived from (R)-(-)-phenylglycinol and a series of chiral epoxides.

Full text of DOI:10.1016/S0040-4039(99)01530-0

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