Synthesis and binding properties of photoactivable biotin-conjugated verapamil derivatives for the study of P-170 glycoprotein

DOI: 10.1016/S0968-0896(99)00104-2

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Bioorganic and Medicinal Chemistry p. 1873 - 1880 (1999)

Update date:2022-08-04

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Authors:

Teodori, Elisabetta

Ettori, Dominique

Garnier-Suillerot, Arlette

Gualtieri, Fulvio

Manetti, Dina

Novella Romanelli, Maria

Scapecchi, Serena

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Article abstract of DOI:10.1016/S0968-0896(99)00104-2

The design and synthesis of two photoactivable biotin-labeled analogues of verapamil (6 and 7) is reported. Preliminary evaluation of the biological profile of 6 (EDP 137) and 7 (EDP 141) shows that they have comparable affinities to that of verapamil for

Full text of DOI:10.1016/S0968-0896(99)00104-2

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