2-naphthylcarbapenems: Broad spectrum antibiotics with enhanced potency against MRSA

DOI: 10.1016/S0960-894X(99)00500-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2893 - 2896 (1999)

Update date:2022-07-30

Topics: NMR spectroscopy Organic synthesis Drug Resistance MIC assay

Authors:

Greenlee, Mark L.

DiNinno, Frank

Herrmann, Jeffrey J.

Jaworsky, Cynthia

Muthard, David A.

Salzmann, Thomas N.

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Article abstract of DOI:10.1016/S0960-894X(99)00500-4

A regioisomeric set of 2-naphthylcarbapenems featuring cationic substituents was synthesized. Optimal placement of the cationic group was found to markedly improve activity against methicillin-resistant staphylococci while maintaining a good spectrum of gram-negative activity.

Full text of DOI:10.1016/S0960-894X(99)00500-4

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