Bioorganic and Medicinal Chemistry Letters p. 2893 - 2896 (1999)
Update date:2022-07-30
Topics: NMR spectroscopy Organic synthesis Drug Resistance MIC assay
Greenlee, Mark L.
DiNinno, Frank
Herrmann, Jeffrey J.
Jaworsky, Cynthia
Muthard, David A.
Salzmann, Thomas N.
A regioisomeric set of 2-naphthylcarbapenems featuring cationic substituents was synthesized. Optimal placement of the cationic group was found to markedly improve activity against methicillin-resistant staphylococci while maintaining a good spectrum of gram-negative activity.
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Doi:10.1002/(SICI)1099-1395(199910)12:10<751::AID-POC190>3.0.CO;2-P
(1999)Doi:10.1021/np990277g
(1999)Doi:10.1080/00397919708003379
(1997)Doi:10.1021/jo0602726
(2006)Doi:10.1016/S0960-894X(01)00331-6
(2001)Doi:10.1021/jo991052d
(1999)
