Asymmetric synthesis of the 4-hydroxymethyl-2-oxazolidinone from the serinol derivative and chloroformates

DOI: 10.1016/S0040-4039(99)01548-8

Source and publish data:

Tetrahedron Letters p. 7489 - 7492 (1999)

Update date:2022-08-04

Topics:

Authors:

Sugiyama, Shigeo

Watanabe, Shoko

Ishii, Keitaro

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Article abstract of DOI:10.1016/S0040-4039(99)01548-8

Asymmetric desymmetrization of 2-[(αR)-α-methylbenzyl]amino-1,3-propanediol (1) with 2-chloroethyl chloroformate and DBU at room temperature gave optically active (4S)-4-hydroxymethyl-N-[(αR)-α-methylbenzyl]-2-oxazolidinone [(4S)-2] (up to 94% de). This r

Full text of DOI:10.1016/S0040-4039(99)01548-8

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