ACS Medicinal Chemistry Letters p. 461 - 465 (2015)
Update date:2022-08-05
Topics:
Yang, Christine
Balsells, Jaume
Chu, Hong D.
Cox, Jason M.
Crespo, Alejandro
Ma, Xiuying
Contino, Lisa
Brown, Patricia
Gao, Sheng
Zamlynny, Beata
Wiltsie, Judyann
Clemas, Joseph
Lisnock, Jeanmarie
Gibson, Jack
Zhou, Gaochao
Garcia-Calvo, Margarita
Bateman, Thomas J.
Tong, Vincent
Xu, Ling
Crook, Martin
Sinclair, Peter
Shen, Hong C.
Elaboration of the oxazolidinedione series led to replacement of the exocyclic amides with substituted benzimidazoles. The structure-activity relationship (SAR) exploration resulted in the discovery of potent and selective nonsteroidal mineralocorticoid receptor (MR) antagonists with significantly improved microsomal stability and pharmacokinetic (PK) profile relative to the HTS hit 1a. One compound 2p possessed comparable efficacy as spironolactone (SPL) at 100 mg/kg (p.o.) in the rat natriuresis model. As such, this series was validated as a lead series for further optimization.
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