An efficient synthesis of (pyrrolidin-2-ylidene)glycinate using intramolecular 1, 3-dipolar cycloaddition of azide and olefin

Article abstract of DOI:10.1016/S0040-4020(99)00753-X

Methyl and tert-butyl (E-)-(pyrrolidin-2-ylidene)glycinates 3a and 3b were efficiently and stereoselectively synthesized from 2, 3, 5-tri-O- benzylarabinose using Horner-Emmons olefination of arabinal 9 and phosphorylglycine ester and intramolecular 1, 3-