Temperature-effected tuning of enantioselectivity in asymmetric catalysis

Article abstract of DOI:10.1016/S0040-4039(98)00459-6

Asymmetric desymmetrization in chiral organotin-catalyzed reaction of 2- substituted 1,3-propanediol with phenyl isocyanate exhibits a linear variation of %ee depending on the reaction temperature and, thus, the chirality sense is inverted from one enanti