Tetrahedron Letters p. 5055 - 5058 (1993)
Update date:2022-07-29
Topics:
Patonay
Toth
Adam
2'-Hydroxychalcone epoxides were found to give trans-3-hydroxyflavanone and 2-(α-hydroxybenzyl)-3-coumaranone under basic conditions. Epoxidation of 2'-hydroxychalcones with dimethyldioxirane followed by treatment of tetrabutylammonium hydroxide provides a convenient and general method for the synthesis of trans-3-hydroxyflavanones.
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