Peroxides as oxidative enzyme inhibitors: Mechanism-based inhibition of a cysteine protease by an amino acid ozonide

Article abstract of DOI:10.1016/S0960-894X(99)00563-6

A stable ozonide derived from Cbz-L-Phe accomplishes rapid and stoichiometric inhibition of papain at less than 100 μM concentration under conditions where formation of the corresponding aldehyde is negligible. Oxidation of the active site thiolate by the