Studies on pyrrolidinone. Synthesis of aza analogs of podophyllotoxin and related compounds

Article abstract of DOI:10.1002/jhet.5570360525

The Friedel-Crafts cyclisation of N-benzhydrylpyroglutamic acids whose aromatic rings are substituted by methoxy or methylenedioxy groups gives podophyllotoxin analogs whose lactone ring was changed to a lactam.