Asymmetric palladium annulation: Formal synthesis of (+)-huperzine A

Article abstract of DOI:10.1016/S0040-4039(99)01874-2

A new formal stereoselective synthesis of (+)-huperzine A 1 was achieved using as a key step a palladium mediated annulation between 2-methylene-1,3- propanediol diacetate and (1R,2S)-2-phenylcyclohexanol derived β-ketoester 14.