A new scaffold for dipeptide β-turn mimetics: Expeditious synthesis of an unsaturated 6,5-fused bicyclic lactam

Article abstract of DOI:10.1002/jhet.5570360527

Reported here is an easy and short synthesis of 6-acetamido-5-oxo- 1,2,3,5,6,7-hexahydro-3-indolizine-carboxylic acid, originating from β- enaminoesters derived from pyroglutamic acid. This key compound has been used as a scaffold in the synthesis of dipeptido mimetics.