Journal of Heterocyclic Chemistry p. 1285 - 1289 (1999)
Update date:2022-08-05
Topics:
Kim, Hong-Seok
Kwon, II-Chun
Choi, Jun-Hyeak
Crown ethers containing a thiazole subcyclic unit are prepared from the reactions of 1,3-bis[2(4-hydroxymethylthiazoyl)]benzene with di-p-tosylates of corresponding di, tri, tetra, pentaethylene glycols in the presence of potassium hydride. However, if the cavity size in the ring system is small, [2+2] cyclization adduct also is formed.
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Doi:10.1016/S0040-4020(99)00773-5
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