INTRAMOLECULAR NICKEL CATALYZED CYCLOADDITIONS OF BIS-DIENES: 3 APPROACHES TO THE TAXANE SKELETON

Article abstract of DOI:10.1016/S0040-4039(00)96085-4

The successful application of the nickel catalyzed, intamolecular <4+4> cycloaddition of bis-dienes to the preparation of both the AB and BC ring systems of the taxane diterpenes is described.This cycloaddition methodology provides the basis for a general