Synthesis, antiviral and antibacterial activities of isatin mannich bases

Article abstract of DOI:10.1007/s00044-005-0135-x

HIV is the most significant risk factor for many opportunistic infections like tuberculosis, hepatitis, bacterial infections etc. We designed an isatin lead compound as a novel non-nucleoside reverse transcriptase inhibitor with broad-spectrum chemotherapeutic properties for the effective treatment of AIDS and AIDS-related opportunistic infections. Compound 1-cyclopropyl-6-fluoro-1,4- dihydro-4-oxo-7-[[N⁴-[3′-(4′-amino-5′- trimethoxybenzyl pyrimidin-2′-yl)imino-1′-(5-chloroisatinyl)]methyl] -N¹-piperazinyl]-3-quinoline carboxylic acid (14) emerged as the most potent broad-spectrum chemotherapeutic agent active against HIV, HCV, M. tuberculosis and various pathogenic bacteria. Birkhaeuser Boston 2006.

Full text of DOI:10.1007/s00044-005-0135-x

Med Chem Res 14:4 (2005) 211–228
௠ Birkha¨user Boston 2006
DOI: 10.1007/s00044-005-0135-x

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Received:
1/4/05
Accepted:
10/20/05
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