Bioorganic and Medicinal Chemistry Letters p. 419 - 422 (2000)
Update date:2022-08-05
Topics:
Ohkubo, Mitsuru
Nishimura, Teruyuki
Kawamoto, Hiroshi
Nakano, Masato
Honma, Teruki
Yoshinari, Tomoko
Arakawa, Hiroharu
Suda, Hiroyuki
Morishima, Hajime
Nishimura, Susumu
A new indolocarbazole compound, NB-506 (1), modified at the glucose group yielded a β-D-glucopyranoside, J-107,088 (2), which showed potent anticancer activity. A β-D-ribofuranoside, J-109,534 (3), was found to be 6 times more potent than J-107,088 at inhibiting topoisomerase I. (C) 2000 Elsevier Science Ltd. All rights reserved.
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