Natural Product Research p. 2618 - 2622 (2019)
Update date:2022-08-05
Topics:
Gundoju, Narayanarao
Bokam, Ramesh
Yalavarthi, Nageswara Rao
Azad, Rajaram
Ponnapalli, Mangala Gowri
Chemical manipulation studies were conducted on betulinic acid (1), twenty-one new rationally designed analogues of 1 with modifications at C-28 were synthesized for their evaluation of inhibitory effects on α-glucosidase and LPS-stimulated nitric oxide production in mouse macrophage RAW 264.7 cells. Compound 2 (IC50 = 5.4 μM) exhibited an almost 1.4-fold increase in α-glucosidase inhibitory activity on yeast α-glucosidase while analogues 5 (IC50 16.4 μM) and 11 (IC50 16.6 μM) exhibited a 2-fold enhanced inhibitory activity on NO-production than betulinic acid.
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