Synthesis and evaluation of some hydroxyproline-derived peptidomimetics as isoprenyltransferase inhibitors

DOI: 10.1248/cpb.48.740

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 740 - 742 (2000)

Update date:2022-08-03

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Authors:

O'Connell, Celeste E.

Rowell, Cheryl A.

Ackermann, Karen

Garcia, Ana Maria

Lewis, Michael D.

Kowalczyk, James J.

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Article abstract of DOI:10.1248/cpb.48.740

CA₁A₂X peptidomimetics containing a modified proline at position A₂ were prepared and evaluated for their ability to inhibit farnesyltransferase (FTase) and geranylgeranyltransferase I (GGTase I) in enzymatic and cell- bas

Full text of DOI:10.1248/cpb.48.740

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