Bioorganic and Medicinal Chemistry Letters p. 783 - 786 (2004)
Update date:2022-09-26
Topics:
Khire, Uday R.
Bankston, Donald
Barbosa, James
Brittelli, David R.
Caringal, Yolanda
Carlson, Robert
Dumas, Jacques
Gane, Todd
Heald, Sarah L.
Hibner, Barbara
Johnson, Jeffrey S.
Katz, Michael E.
Kennure, Nancy
Kingery-Wood, Jill
Lee, Wendy
Liu, Xiao-Gao
Lowinger, Timothy B.
McAlexander, Ian
Monahan, Mary-Katherine
Natero, Reina
Renick, Joel
Riedl, Bernd
Rong, Hong
Sibley, Robert N.
Smith, Roger A.
Wolanin, Donald
Bis-aryl ureas have been disclosed previously as a potent class of Raf kinase inhibitors. Modifications in the amide portion led to an improvement in aqueous solubility, an important characteristic for an oral drug. Based on this finding, we hypothesize t
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