Tetrahedron Letters p. 6843 - 6847 (2000)
Update date:2022-08-03
Topics:
Sakai, Yasuhiro
Oikawa, Masato
Yoshizaki, Hiroaki
Ogawa, Tomohiko
Suda, Yasuo
Fukase, Koichi
Kusumoto, Shoichi
Synthesis of lipid A 1 isolated from Helicobacter pylori strain-206-1 has been achieved in 2.2% total yield through 14 steps from D-glucosamine by employing a p-(trifluoromethyl)benzyl group for protection of the hydroxy group on the 3-hydroxy fatty acid residue. The synthetic specimen was identical with the natural counterpart in chromatographic, spectroscopic, and biological aspects. A structural analogue 2 which lacks the ethanolamine residue of 1 was also synthesized, and 2 was found to exhibit less potent IL-1β-inducing activity than 1. (C) 2000 Elsevier Science Ltd.
View MoreShandong Xiangde Biotechnology Co., Ltd
Contact:+86 -15066639877
Address:Sanba street
Tianjin SPHINX SCIENTIFIC LAB.
Contact:+86-022-66211289
Address:Tianda high-tech Park. No.80,the 4th Avenue
Zhengzhou Xinlian Chemical Tech Co. ,Ltd
Contact:0371-65771781 021-52042910
Address:H Part, Building I, No. 700 Gonglu Road, Pudong New Area, Shanghai
Jurong Huaheng Natural Biological Products Factory
website:http://www.risebiochem.com
Contact:+86-13921007726
Address:Chuncheng town,Jurong city,Jiangsu province,China
Yancheng Creator Chemical Co., Ltd
Contact:0086-515-88710008 88710068 88710858 88710868
Address:No.21 Renming Road, Longgang Town, Yandu County,Yancheng City
Doi:10.1016/S0008-6215(00)85618-9
(1981)Doi:10.1039/c39820000930
(1982)Doi:10.1515/HC.2011.042
(2011)Doi:10.1021/jo000781m
(2000)Doi:10.1002/ardp.19703030712
(1970)Doi:10.1021/ja000686v
(2000)