Bioorganic and Medicinal Chemistry Letters p. 1459 - 1462 (2000)
Update date:2022-09-26
Topics:
Masubuchi, Kazunao
Taniguchi, Mikio
Umeda, Isao
Hattori, Kazuo
Suda, Hitomi
Kohchi, Yasunori
Isshiki, Yoshiaki
Sakai, Toshiya
Kohchi, Masami
Shirai, Michio
Okabe, Hisafumi
Sudoh, Masayuki
Yamazaki, Toshikazu
Shimma, Nobuo
A novel Candida albicans chitin synthase 1 (CaChs1) inhibitor, RO-41-0986 (1) was discovered by random screening. Systematic modification led to the identification of a highly potent CaChs1 inhibitor, RO-09-3024 (2), having strong antifungal activity against Candida spp. in vitro. (C) 2000 Elsevier Science Ltd. All rights reserved.
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