A-C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions

DOI: 10.1021/acs.jmedchem.7b01601

Source and publish data:

Journal of Medicinal Chemistry p. 4720 - 4738 (2018)

Update date:2022-08-15

Topics:

Authors:

Hanson, Alicia M.

Perera, K. L. Iresha Sampathi

Kim, Jaekyoon

Pandey, Rajesh K.

Sweeney, Noreena

Lu, Xingyun

Imhoff, Andrea

Mackinnon, Alexander Craig

Wargolet, Adam J.

Van Hart, Rochelle M.

Frick, Karyn M.

Donaldson, William A.

Sem, Daniel S.

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Article abstract of DOI:10.1021/acs.jmedchem.7b01601

Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A-C estrogens, lacking the B and D estrogen rings. The

Full text of DOI:10.1021/acs.jmedchem.7b01601

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