Synthesis of azabicycloalkane amino acid scaffolds as reverse-turn inducer dipeptide mimics

Article abstract of DOI:10.1002/1099-0690(200007)2000:14<2571::aid-ejoc2571>3.0.co;2-d

In an effort to design dipeptide structural mimics of protein and peptide reverse-turns, a series of 5,5-, 6,5-, and 7,5-fused 2-oxo-1- azabicycloalkane amino acids has been synthesized. A new and convenient synthetic route utilizing a Horner-Emmons react