Irreversible inhibitions of serine proteases by peptidyl allylic halide derivatives

Article abstract of DOI:10.1016/0960-894X(95)00592-H

Peptidyl 4-amino-5-phenyl-2-pentenyl bromide (7a, 9a, 10a) and chloride derivatives (7b, 9b, 10b) were found to be active-site directed irreversible inhibitors of α-chymotrypsin but did not show any irreversible inhibitory activity toward porcine pancreatic elastase. Copyright