First total synthesis of sialylated and sulfated Lewis(x) mucin Core 2 structures as potential tumor associated antigens

Article abstract of DOI:10.1016/S0040-4039(00)00975-8

Two branched Core 2 structures, (3-O-SO₃Na)Galβ1→4(Fucα1→3)GlcNAcβ1→6(NeuAcα2→3Galβ1→3)Ga1NAcαOMe (1) and its positional isomer NeuAcα2→3Galβ1→4(Fucα1→3)GlcNAcβ1→6(3-OSO₃Na-Galβ1→3)GalNAcαOMe (2), were chemically synthesized for the first time as potential tumor associated antigens. (C) 2000 Elsevier Science Ltd.