Cis-unsaturated analogues of 3,8,13,18,23-pentaazapentacosane (BE-4-4-4-4): Synthesis add growth inhibitory effects on human prostate cancer cell lines

Article abstract of DOI:10.1021/jm000310s

From the results of our previous physicochemical studies of polyamine - Nucleic acid interactions, we concluded that polyamine analogues in cisoidal conformation are capable of wrapping around the major groove of the double helix, of displacing natural po