Selective aminoacylation of nucleosides through an enzymatic reaction with oxime aminoacyl esters

Article abstract of DOI:10.1016/S0040-4020(01)81345-4

N-protected aminoacyl acetoxime esters are useful agents for enzymatic aminoacylation of 2'-deoxy- and ribo-nucleosides. In both cases, 5'-O- derivatives can be prepared if the lipase used is SP 435 (from Candida antarctica) whereas 3'-O-isomers from 2'-deoxynucleosides are obtained with Pseudomonas cepacia.