Synthesis of bicyclic azacompounds (3-dimethylcarbamoyloxyphenyl) substituted as acetylcholinesterase inhibitors

Article abstract of DOI:10.1002/jhet.5570370422

This paper describes the synthesis of some bicyclic 2-(3-dimethylcarbamoyloxyphenyl) substituted azaderivatives, obtained from 1,4- and 1,5-diketones, which were cyclized with ammonium acetate, methylamine and by reductive amination. Corresponding 3-substituted derivatives were instead prepared by reaction of 1,5-ketoesters with formamide. The carbamates were tested as in vitro acetylcholinesterase inhibitors.