
Journal of Heterocyclic Chemistry p. 799 - 810 (2000)
Update date:2022-09-26
Topics:
Borioni
Del Giudice
Mustazza
Gatta
This paper describes the synthesis of some bicyclic 2-(3-dimethylcarbamoyloxyphenyl) substituted azaderivatives, obtained from 1,4- and 1,5-diketones, which were cyclized with ammonium acetate, methylamine and by reductive amination. Corresponding 3-substituted derivatives were instead prepared by reaction of 1,5-ketoesters with formamide. The carbamates were tested as in vitro acetylcholinesterase inhibitors.
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Doi:10.1021/om0003133
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