Preparation of novel synthons, uniquely functionalized tetrahydrofuran and tetrahydropyran derivatives

Article abstract of DOI:10.1248/cpb.48.1581

The dianion of the acetoacetic ester reacts with epibromohydrin derivatives to afford a mixture of (Z)-2-alkoxycarbonylmethylidenetetrahydrofuran derivative and (E)-2-alkoxycarbonylmethylidenetetrahydropyran derivative. The selective formation of the tetr