Preparation of novel synthons, uniquely functionalized tetrahydrofuran and tetrahydropyran derivatives

DOI: 10.1248/cpb.48.1581

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1581 - 1585 (2000)

Update date:2022-08-03

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Authors:

Nakada, Masahisa

Takano, Masashi

Iwata, Yukitaka

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Article abstract of DOI:10.1248/cpb.48.1581

The dianion of the acetoacetic ester reacts with epibromohydrin derivatives to afford a mixture of (Z)-2-alkoxycarbonylmethylidenetetrahydrofuran derivative and (E)-2-alkoxycarbonylmethylidenetetrahydropyran derivative. The selective formation of the tetr

Full text of DOI:10.1248/cpb.48.1581

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