Carbon-14 labeling of a potential new immunoregulant agent

DOI: 10.1002/1099-1344(20001015)43:11<1095::AID-JLCR395>3.0.CO;2-3

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 1095 - 1105 (2000)

Update date:2022-08-03

Topics: Animal Studies Elimination Regulatory Approval Toxicity Studies Pharmacokinetics and Pharmacodynamics Metabolism Human Studies

Authors:

McEvoy Egan

Dean Dean

Marks Marks

Song, Zhiguo

Melillo Melillo

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Article abstract of DOI:10.1002/1099-1344(20001015)43:11<1095::AID-JLCR395>3.0.CO;2-3

A carbon-14 labeled version of the ascomycin analog 1, a potential new immunosuppressant agent, was synthesized for utilization in animal and human drug metabolism studies. In order to place the carbon-14 label at a metabolically stable position, it was n

Full text of DOI:10.1002/1099-1344(20001015)43:11<1095::AID-JLCR395>3.0.CO;2-3

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